What binds to an mRNA codon during polypeptide synthesis?

During polypeptide synthesis, it is the tRNA anticodon that binds to an mRNA codon. Each tRNA molecule has a specific anticodon that is complementary to a corresponding codon on the mRNA strand. This complementary base pairing ensures that the correct amino acid is brought to the ribosome, where protein synthesis occurs.

The tRNA molecule aligns itself with the mRNA strand in such a way that its anticodon matches the codon on the mRNA. This process facilitates the incorporation of the correct amino acid into the growing polypeptide chain. The accuracy of this interaction is crucial for the proper translation of genetic information into functional proteins. Thus, the role of the tRNA anticodon is essential in decoding the mRNA during translation, ensuring that the protein is synthesized accurately according to the genetic code.